Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT2AR) modulators.
PLoS Computational Biology September 1, 2025 Jordy Peeters, Dimitri de Bundel, Kenno Vanommeslaeghe
The serotonin-2A receptor (5-HT2AR) is an interesting target for drug design in the context of antidepressants that might have a rapid onset of action and/or be effective in treatment-resistant cases. The main challenge, however, is that the activation of this receptor can provoke hallucinations. Recent studies have shown that activating the receptor with certain (partial) agonists could...