Depression is one of the most common mental health challenges people face today. It goes beyond just feeling sad — it shapes the way a person thinks, behaves, and experiences the world around them. The persistent low mood, the fading interest in things that once brought joy, the fog that makes even simple decisions feel overwhelming — all of it quietly chips away at a person's quality of life....
Major depressive disorder (MDD) is a complex psychiatric condition associated with alterations in brain neuroplasticity. Brain-derived neurotrophic factor (BDNF), a key regulator of neuronal survival, synaptic plasticity, and neurogenesis, has been widely studied as a biological marker of neuroplasticity in depression. This review and meta-analysis evaluated the relationship between BDNF levels...