Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
Molecular Psychiatry March 1, 2026 Tyler G. Ekins, Chloe Rybicki-Kler, Tao Deng et al. 9 citations
Classical psychedelic drugs show promise as a treatment for major depressive disorder and related psychiatric disorders. This therapeutic efficacy stems from long-lasting psychedelic-induced neuroplasticity onto prefrontal cortical neurons and is thought to require the postsynaptic expression of serotonin 2A receptors (5-HT_2AR). However, other cortical regions such as the granular...