Classic psychedelics in obsessive–compulsive disorder: a circuit-based framework
Nature Mental Health April 1, 2026 Saif S. Ali, Robin Carhart-Harris, Karl G. Sieg
Obsessive–compulsive disorder (OCD) is a psychiatric condition with high rates of treatment resistance. Emerging neuroimaging evidence implicates dysfunction in large-scale brain networks, particularly the cortico–striatal–thalamo–cortical (CSTC) circuit, default mode network (DMN) and salience network (SN). Lysergic acid diethylamide (LSD) and psilocybin induce acute dysregulation of the DMN...