Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications
Molecular Psychiatry July 3, 2026 Yu Wang, Ji-Tao Li, Lin-Lin Zhu et al.
Despite its high prevalence, the precise mechanisms underlying major depressive disorder (MDD) remain incompletely understood. Growing evidence identifies mitochondrial dysfunction, including abnormalities in mitochondrial DNA, impaired bioenergetics, disrupted quality control, and redox imbalance, as a central pathological feature of MDD. Beyond deficits in energy production, mitochondria...