Psilocybin Attenuates Cortical Representations of Aversion in the Mouse Auditory Cortex.
bioRxiv : the preprint server for biology March 27, 2026 James D. Johnson, Runyi Tian, Yasaman Etemadi et al.
Psilocybin can produce sustained benefits in affective and trauma-related disorders, yet if and how it reshapes sensory representations of learned valence associations remains largely unclear. To address this, we used longitudinal two-photon calcium imaging in awake C57BL/6 mice to examine how psilocybin modulates layer 2/3 auditory cortex activity at single-cell and population levels. Evoked...