Blinding integrity in psychedelic research: Evidence from a comparative randomized controlled trial of psilocybin, MDMA, and methylphenidate in healthy volunteers.
European Neuropsychopharmacology May 28, 2026 L Belinger, Nathalie M. Rieser, Etna Engeli et al.
Maintaining effective blinding is a major methodological challenge in psychedelic research. This study provides a comprehensive evaluation of blinding integrity in 120 healthy volunteers who received either psilocybin, MDMA, or methylphenidate (active placebo) in a double-blind, randomized controlled trial. Using a multi-level assessment incorporating forced-choice substance guesses, certainty...
DOI: 10.1016/j.euroneuro.2026.112879 (opens in new tab)
Full text (opens in new tab)
MDMA
Psilocybin
Blinding assessment
Blinding integrity
+2