Time to embrace the whole: considering the replacement of psilocybin with Psilocybe spp. in psychedelic research and therapy.
Natural Product Research June 2, 2026 Genís Ona, Cristina Llagostera, Oscar Alvarez et al.
Psilocybin, the main psychoactive compound in Psilocybe cubensis mushrooms, has gained considerable attention for its therapeutic potential. Current research focuses only on isolated psilocybin, neglecting the broader pharmacological and cultural use of the whole mushroom. This perspective advocates for an integrative approach that includes standardised P. cubensis extracts within the...