Dextromethorphan Beyond the Cough: Exploring Its Psychedelic Potential: A Systematic Review
CNS Drugs June 15, 2026 Edward P. Hackett, Aditi Chaudhri -, Linda Hasman et al.
BACKGROUND AND OBJECTIVE: Dextromethorphan (DXM), widely used as an over-the-counter antitussive in the United States, exhibits psychoactive effects at supratherapeutic levels that overlap with those of classic and dissociative psychedelics. Reported psychoactive effects have generated interest in DXM as a potential therapeutic agent for treatment-resistant psychiatric disorders. Despite this...
DOI: 10.1007/s40263-026-01305-9 (opens in new tab)
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Psilocybin
Dextromethorphan
Tolerability
Observational study
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