NMDA antagonist properties of the putative antiaddictive drug, ibogaine.
Journal of Pharmacology and Experimental Therapeutics November 1, 1995 Piotr Popik, Richard T. Layer, Linda H. Fossom et al. 100 citations
Both anecdotal reports in humans and preclinical studies indicate that ibogaine interrupts addiction to a variety of abused substances including alcohol, opiates, nicotine and stimulants. Based on the similarity of these therapeutic claims to recent preclinical studies demonstrating that N-methyl-D-aspartate (NMDA) antagonists attenuate addiction-related phenomena, we examined the NMDA...