Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation
PLoS One April 21, 2017 Emilia M. Lefevre, Gregory Medley, Timothy Reeks et al. 8 citations
Stress is known to modulate sensitisation to repeated psychostimulant exposure. However, there is no direct evidence linking glucocorticoids and sensitisation achieved by repeated administration of the NMDA receptor antagonist MK-801. We tested the hypothesis that co-administration of RU486, a glucocorticoid receptor (GR) antagonist, prior to repeated daily MK-801 injections would block the...