Pharmacological Evaluation of Tropane Analogues at the Serotonin Transporter.
ACS Chemical Neuroscience September 3, 2025 Arabo A. Avanes, Hunter T Warren, Abinaya Senthil et al. 2 citations
Tropane alkaloids and their derivatives represent a diverse class of small molecules with a broad range of therapeutic applications. Many tropanes regulate synaptic levels of neuromodulators by interacting with monoamine transporters such as dopamine (DAT) and serotonin (SERT) transporters. While DAT inhibition plays an important role in the addictive potential of tropanes such as cocaine,...