Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids.
European journal of organic chemistry September 23, 2024 Alexander J Hughes, Charles R Hamelink, Steven D Townsend 5 citations
The iboga alkaloids are a family of monoterpene indole alkaloids first discovered from the root of Tabernanthe iboga. The major alkaloid constituent in the root, ibogaine, has garnered interest for its anti-addictive properties. Ibogaine has been shown to reduce opiate, amphetamine, alcohol, and nicotine self-administration in rodents. However, ibogaine itself is less than optimal as a...