Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats.
Neuropsychopharmacology April 19, 2025 Valeria Grasso, Joseph Tennyson, Raag D. Airan et al. 5 citations
Subanesthetic ketamine is currently used as a rapid-acting treatment for varied neuropsychiatric disorders. However, the mechanistic underpinnings of its therapeutic action remain unclear, and emerging clinical and preclinical evidence highlights a potential involvement of the opioid system. We used pharmacological functional ultrasound imaging data acquired during and after ketamine...
DOI: 10.1038/s41386-025-02108-0 (opens in new tab)
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Psychopharmacology
Depression treatment
Sex differences
Brain connectivity