Noribogaine altered intrinsic properties of thalamocortical neurons in a sex-dependent manner
Progress in Neuro-psychopharmacology and Biological Psychiatry August 1, 2025 Sofía Villalba, Sofia Bosch, Lucia di Constanzo et al. 1 citation
Noribogaine (Noribo) is the primary metabolite from ibogaine, an atypical psychedelic. The main objective of this study was to evaluate the effect of Noribo on thalamic physiology of calcium channels voltage activation and gene expression and the potential involvement of the 5-HT2A receptor on those effects. Thus, we used male and female, 5-HT2AR knockout (KO) and wild type (WT) mice, injected...