September 11, 2026Joseph M. Diehl, Christina Chwyl, Liliana Kennedy et al.
preprint
The therapeutic relationship is considered central to psychedelic-assisted therapy, yet little empirical research has examined how it changes during 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) or relates to acute MDMA experiences and clinical outcomes, particularly for social anxiety disorder (SAD). This preregistered secondary analysis examined therapeutic alliance and...
August 23, 2025Joseph M. Diehl, M. Zachary Rosenthal
preprint
Psychedelic-assisted psychotherapy (PAP) has emerged as a promising intervention for conditions such as depression, PTSD, and substance use disorders by enhancing the therapeutic potential of psychedelics with structured psychological support during preparation, dosing, and integration phases. Despite encouraging trial results, evidence for therapeutic mechanisms and optimal frameworks for PAP...