Chronic, combinatorial targeting of NMDARs and 5-HT4Rs exerts extended behavioral effects against stress-induced perseverative behavior and hyponeophagia.
Neuropsychopharmacology April 22, 2025 Briana K Chen, Alicia Whye, Louise C Matthews et al. 2 citations
Serotonin (5-HT) receptors and N-methyl-D-aspartate receptors (NMDARs) have both been implicated in stress-induced psychiatric disorders. However, there is a paucity of studies evaluating the effectiveness of novel combinatorial pharmacological treatments to treat stress-related disorders. Here, we evaluated whether administration of combinatorial (R,S)-ketamine, an NMDAR antagonist and Food...
DOI: 10.1038/s41386-025-02107-1 (opens in new tab)
Full text (opens in new tab)
Mental health
Psychopharmacology
Anxiety treatment
Drug therapy
+1