Psychedelics Promote Structural and Functional Neural Plasticity
Cell Reports June 1, 2018 Calvin Ly, Alexandra C. Greb, Lindsay P. Cameron et al. 1,158 citations
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of...