Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
American Journal of Psychiatry August 29, 2018 Nolan Williams, Boris D. Heifets, Christine Blasey et al. 510 citations
OBJECTIVE: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its acute antidepressant or dissociative effects. METHOD: In a proposed double-blind crossover study of 30 adults with treatment-resistant...