The sigma-1 receptor: a mechanistically-informed therapeutic target for antidepressants.
Expert Opinion on Therapeutic Targets June 1, 2025 Naomi Xiao, Liyang Yin, Kayla M Teopiz et al. 5 citations
The mechanism of action of antidepressants is not fully ascertained. In addition to monoamines, disparate other effectors are also implicated in the molecular and cellular effects of chronic stress including neurogenesis, neurodifferentiation, and neuroplasticity. Evidence suggests sigma-1 receptors (S1Rs) as a putative target and possible mediator of antidepressant activity. Data from...