Sex-dependent developmental changes in behavior, brain structure, functional connectivity, and sensory perception following exposure to psilocybin during adolescence
Neuropsychopharmacology February 18, 2026 Itishree Sahoo, Sairam Masadi, Ashwath Maheswari et al. 3 citations
Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. We hypothesized psilocybin given during adolescence, a time of heightened neuroplasticity, particularly in the forebrain, would affect emotional behavior and the associated underlying neuroanatomy, neurocircuitry, and epigenetics. Female and male mice...
DOI: 10.1038/s41386-026-02356-8 (opens in new tab)
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Psilocybin
Neuroplasticity
Prefrontal cortex
Hallucinogen
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