Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists.
Asian Journal of Psychiatry June 1, 2025 Mingrui Chen, Jingyan Jin, Hongsheng Bi et al. 12 citations
N-methyl-D-aspartate receptors (NMDA receptors) play a crucial role as ionotropic glutamate receptors in regulating neuroplasticity, learning, memory, and a range of psychiatric disorders. Studies indicate that dysfunction of NMDA receptors is a key pathological mechanism in depression, where abnormal activation can result in neuronal excitotoxicity, excessive extracellular calcium ion...