Feasibility of Closed-Loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine: A Randomized Controlled Equivalence Trial.
Drug Design, Development and Therapy 2025 Xiaoshan Li, Shengchao Li, Chanyan Xu et al. 3 citations
This research aimed to quantify the impact of low dose of esketamine on BIS and validate the feasibility of closed-loop TCI system based on the new BIS baseline with low dose of esketamine. This study consisted of two phases. The first phase was to quantify the impact of a low dose of esketamine (0.2mg kg-1 bolus, 5μg kg-1 min-1 infusion for 30min) on BIS and establish a new BIS baseline for...