5mC and 5hmC Detection Highlights How Psychedelics Affect Brain Epigenetic Patterns
Zenodo (CERN European Organization for Nuclear Research) November 4, 2025 Uri Bertocchi, Amit Schwartz, Gali Umschweif et al.
Background: Psilocybin, a serotonergic psychedelic compound, has demonstrated long-term antidepressant effects, yet its underlying mechanisms remain unclear. Emerging evidence suggests that epigenetic modifications, particularly 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), may play a role in its therapeutic action. Unlike passive demethylation, which requires cell division and...