Partial rescue of schizophrenia-related phenotypes in young adult Sp4 hypomorphic mice.
Journal of Psychiatric Research July 1, 2025 Joris Kamp, Megan E Sikkink, Mahalah R Buell et al.
The Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) Consortium found that truncation of one copy of the SP4 gene has an odds ratio of 9.37 (3.38-29.7) for schizophrenia (SCZ). Human SP4 gene is also one of the 69 schizophrenia-risk genes prioritized by parallel genome-wide association studies (GWAS) and one of the two schizophrenia-risk genes shared between the SCHEMA and the GWAS,...