A low-dose combination of esketamine and propofol for general anesthesia induction during category-1 emergency cesarean sections maintained maternal hemodynamic stability without causing neonatal depression. In a case series of 11 patients, the median 1-minute Apgar score was 9 and the 5-minute Apgar score was 10 for all newborns. The mean decision-to-delivery interval was 10.9 minutes. Only one newborn required temporary mask ventilation due to acute fetal distress from placental abruption; no newborns were admitted to the ICU. No episodes of hypotension, intraoperative awareness, reflux aspiration, or adverse psychiatric effects occurred. The strategy appears suitable, but randomized controlled trials are needed to confirm these findings.
A double-blind randomized controlled trial with 75 patients with mild cognitive impairment and insomnia found that mindfulness therapy significantly improved sleep quality, cognitive function, and reduced anxiety and perceived stress compared to health education. The mindfulness group showed significant improvements in sleep and cognition, with confidence intervals indicating reliable effects. EEG data revealed significant differences in delta, theta, beta, and gamma brainwave bands between rest and mindfulness states, suggesting deep relaxation and changes in attention-related brain activity. No deaths or serious adverse events occurred. Mindfulness can be successfully learned by individuals with mild cognitive impairment and is suitable for use in nursing homes.