Challenging Psychedelic Experiences Across DMT, Psilocybin, MDMA, and Ketamine: A Thematic Analysis of User Reports with Exploratory Human-LLM Concordance Analysis
August 28, 2026 Holly Hepburn
Renewed clinical interest in psychedelics has drawn attention to their challenging effects, yet most phenomenological and psychometric work derives from psilocybin, leaving cross-substance variation underexplored. This thesis employed codebook thematic analysis to examine challenging experiences across DMT, psilocybin, MDMA, and ketamine, utilising 146 naturalistic accounts collected from...