Engineering artificial biosynthetic pathways for efficient microbial production of psilocybin and psilocin
Metabolic Engineering November 5, 2025 Cui Guo, Nguyen N T Luu, Maryem M Adwer et al. 5 citations
Psychedelic-assisted therapy is emerging as a highly promising approach for treating depression, with psilocybin, a psychoactive compound in magic mushrooms, gaining the most recognition for its efficacy in treating post-traumatic stress disorder and treatment-resistant depression. However, its low natural abundance makes extraction costly, necessitating alternative production methods. While...
DOI: 10.1016/j.ymben.2025.11.002 (opens in new tab)
Psilocybin
Metabolic engineering
Escherichia coli
Synthetic biology
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