Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
Journal of Neuroinflammation April 10, 2020 Jing Wu, Jianjun Yang, Yan Cao et al. 140 citations
Abstract Background Increasing evidence suggests that multiple or long-time exposure to general anaesthesia (GA) could be detrimental to cognitive development in young subjects and might also contribute to accelerated neurodegeneration in the elderly. Iron is essential for normal neuronal function, and excess iron in the brain is implicated in several neurodegenerative diseases. However, the...