Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model.
Cell Reports May 21, 2025 Lace M Riggs, Sage Aronson, Ta-Chung M. Mou et al. 2 citations
An acute increase in excitatory synaptic transmission contributes to the rapid antidepressant actions of neuroplastogens, including ketamine and its bioactive metabolite, (2R,6R)-hydroxynorketamine (HNK). It is hypothesized that drug-induced metaplastic changes in synaptic strength account for therapeutically relevant behavioral adaptations in vivo. Using the plasticity-deficient Wistar Kyoto...
DOI: 10.1016/j.celrep.2025.115743 (opens in new tab)
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Synaptic plasticity
Treatment-resistant depression
Cp: neuroscience
Wistar kyoto
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