Alessandro Guidotti

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia

Epigenetics April 30, 2009 Dennis R. Grayson, Ying Chen, Erbo Dong et al. 54 citations

The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine). The premise was that abnormal metabolism led to the methylation of biogenic amines in the brains of schizophrenia patients and that these hallucinogenic...