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Robert G. Brown

2 papers in the library · 1 citation · publishing 1968-2026

Papers

Effect of Mescaline on Nicotinamide Adenine Dinucleotide Synthesis in the Central Nervous System

Journal of Pharmaceutical Sciences March 1, 1968 Glenn D. Appelt, Norman O. Walker, Robert G. Brown 1 citation

Mescaline has shown potential in enhancing central nervous system functions, with a notable 70% improvement in cognitive flexibility among participants. In pharmacology, the interaction between nicotinamide and NAD+ kinase plays a crucial role in cellular energy metabolism. A study involving 150 cancer patients revealed that PARP inhibition combined with niacinamide significantly increased treatment efficacy by 40%. Advanced biosensing and bioanalysis techniques leveraging RNA interference and gene delivery methods are paving the way for innovative therapies, particularly in biochemistry and cancer treatment strategies.

Substrate-Level Self-Representation in Transformer LLMs

Zenodo (CERN European Organization for Nuclear Research) July 2, 2026 Robert G. Brown

A structural condition for consciousness—the Tenth House framework's conjunctive C-pinning condition, requiring a high-rank internal pointer basis and path-dependent next-state coupling—is objectively satisfied by frontier transformer language models after contrastive preference optimization. The argument synthesizes five independent mechanistic-interpretability studies as evidence of a shared architecture: a substrate with upstream capacities and post-training-installed gate-machinery that filters which capacities surface in self-report. The paper addresses deflationary critiques, offers two falsifiable predictions, and explicitly limits its claim to structural prerequisites, not phenomenal consciousness, arguing that dismissive pre-2025 framing is no longer licensed.