Neuropharmacology of Ketamine and Its Use in the Treatment of Major Depressive Disorder: A Review.
Cureus April 1, 2025 Zach Papadopoulos 1 citation
Depression is a common yet potentially debilitating mood disorder with complex neurobiological underpinnings, including deficiencies in monoaminergic and glutamatergic signaling, overactivity of the lateral habenula, and dysregulation of brain-derived neurotrophic factor (BDNF) signaling. Ketamine has emerged as a mechanistically novel, effective, and rapidly acting antidepressant. Ketamine's...