Hila Harat

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

Molecular Plant June 3, 2024 Paula Berman, Luis Alejandro de Haro, Ana-Rita Cavaco et al. 15 citations

Mescaline, among the earliest identified natural hallucinogens, holds great potential in psychotherapy treatment. Nonetheless, despite the existence of a postulated biosynthetic pathway for more than half a century, the specific enzymes involved in this process are yet to be identified. In this study, we investigated the cactus Lophophora williamsii (Peyote), the largest known natural producer...