Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy.
Drug Design, Development and Therapy January 1, 2025 Xingyu Geng, Yutian Pu, Ziwei Hu et al. 7 citations
Postoperative sleep disturbance (POSD) is common after breast cancer surgery. In a randomized trial of 100 patients, intraoperative infusion of esketamine combined with dexmedetomidine did not significantly reduce the incidence of POSD compared to control or either drug alone over the first three days. However, on postoperative day 3, each drug alone reduced POSD risk when the other was absent. Dexmedetomidine decreased rapid eye movement (REM) sleep on day 1, while esketamine reduced nighttime awakening time on days 1 and 3. The combination showed no added benefit for POSD, but each drug had distinct effects on sleep architecture.