Bertram Scheller

2 papers in the library · 2 citations · publishing 2018-2025

Papers

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Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.

PLoS Computational Biology June 9, 2025 Jessie Rademacher, Tineke Grent-'t-Jong, Davide Rivolta et al. 2 citations

Ketamine, an NMDA receptor (NMDA-R) antagonist, produces psychotomimetic effects when administered in sub-anesthetic dosages. While previous research suggests that Ketamine alters the excitation/inhibition (E/I)-balance in cortical microcircuits, the precise neural mechanisms by which Ketamine produces these effects are not well understood. We analyzed resting-state MEG data from n = 12...

DOI: 10.1371/journal.pcbi.1013118 Full text Psychopharmacology Ketamine research Neural circuits Brain imaging

Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia.

Brain August 1, 2018 Tineke Grent-'t-Jong, Davide Rivolta, Joachim Gross et al.

Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated as a possible mechanism underlying cognitive deficits and aberrant neuronal dynamics in schizophrenia. To test this hypothesis, we first administered a sub-anaesthetic dose of S-ketamine (0.006 mg/kg/min) or saline in a single-blind crossover design in 14 participants while magnetoencephalographic data were recorded...

DOI: 10.1093/brain/awy175 Full text Ketamine Brain Thalamus Cerebral cortex +10