Studies on the role of dopamine in the degeneration of 5‐HT nerve endings in the brain of Dark Agouti rats following 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration
British Journal of Pharmacology February 1, 1999 María Isabel Colado, Esther O’shea, R Granados et al. 82 citations
We investigated whether dopamine plays a role in the neurodegeneration of 5‐hydroxytryptamine (5‐HT) nerve endings occurring in Dark Agouti rat brain after 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration. Haloperidol (2 mg kg −1 i.p.) injected 5 min prior and 55 min post MDMA (15 mg kg −1 i.p.) abolished the acute MDMA‐induced hyperthermia and attenuated the neurotoxic loss...