Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans
British Journal of Pharmacology March 8, 2012 Cédric M. Hysek, Yasmin Schmid, Anna Rickli et al. 81 citations
BACKGROUND AND PURPOSE The use of ±3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is associated with cardiovascular complications and hyperthermia. EXPERIMENTAL APPROACH We assessed the effects of the α 1 ‐ and β‐adrenoceptor antagonist carvedilol on the cardiostimulant, thermogenic and subjective responses to MDMA in 16 healthy subjects. Carvedilol (50 mg) or placebo was administered 1 h...