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W. A. Harland

1 paper in the library · 38 citations · publishing 1977

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Radioimmunoassay of lysergic acid diethylamide (LSD) in serum and urine by using antisera of different specificities.

Clinical Chemistry February 1, 1977 W A Ratcliffe, S.m. Fletcher, A.c. Moffat et al. 38 citations

Abstract We raised high-titre antisera to two LSD-bovine serum albumin conjugates, one linked via the indole nitrogen, the other via the amide side-chain. The antisera were specific for different parts of the LSD molecule, as demonstrated by cross-reactivity studies with LSD, its metabolites, ergot alkoloids, and closely related compounds. The antisera were used to develop a double-antibody...