Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine.
Toxicology Letters January 22, 2016 Andrea E. Steuer, Martina I. Boxler, Lorena Stock et al.
Neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) is still controversially discussed. Formation of reactive oxygen species e.g. based on elevated dopamine (DA) concentrations and DA quinone formation is discussed among others. Inhibition potential of MDMA metabolites regarding neurotransmitter degradation by catechol-O-methyltransferase and sulfotransferase was described previously....
DOI: 10.1016/j.toxlet.2015.12.001 (opens in new tab)
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MDMA
In vitro
Inhibition
Mao
+1