Guilty by dissociation: Part C: Enantiomeric separation of diphenidine-derived new psychoactive substances (NPS) by polar organic chiral high performance liquid chromatography (HPLC) on polysaccharide-based stationary phases.
Journal of Pharmaceutical and Biomedical Analysis June 15, 2025 Melvin R Euerby, Benjamin S Barrett, Andrew Costello et al.
This study describes a simple and practical HPLC analysis for the direct enantiomeric separation of a range of 32 novel diphenidine derived psychoactive substances using a range of six polysaccharide-based chiral stationary phases employing a single generic polar organic solvent chromatographic mobile phase. Temperature was employed to optimize the chemo and enantiomeric selectivity. Baseline...