Marek Wiergowski

2 papers in the library · publishing 2014-2025

Papers

Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS.

Molecules (Basel, Switzerland) November 18, 2025 Agata Kot-Wasik, Agnieszka Potęga, Justyna Aszyk-Woźniak et al.

Electrochemical oxidation of the psychoactive substance 25B-NBOMe in a flow cell produced key phase I metabolites—hydroxylated and N-desalkylated products along with dehydrogenated derivatives—and smaller amounts of O-desmethylated and bis-O,O-desmethylated forms. The O-desmethylated metabolite was also found in gastric contents, blood, and urine from severely intoxicated individuals. Phase II metabolites (glucuronide and sulfonate conjugates) appeared only in biological samples. The electrochemical method rapidly generated potential in vivo metabolites, partially matching authentic human samples, supporting its use as a screening tool for metabolism and toxicological risk assessment of novel psychoactive substances.

DOI: 10.3390/molecules30224450 Full text 25b-nbome Hplc-q-tof-ms Biological samples analysis Forensic toxicology +2

Acute methoxetamine and amphetamine poisoning with fatal outcome: A case report

International Journal of Occupational Medicine and Environmental Health January 1, 2014 Marek Wiergowski, Jacek Anand, Maciej Krzyżanowski et al.

A 31-year-old man died after taking methoxetamine (MXE) and amphetamine recreationally. He arrived at the hospital in a deep coma with respiratory failure, hyperthermia, seizures, and signs of organ damage. Despite intensive care, he died four weeks later from multi-organ failure. Blood tests showed MXE at a toxic level (0.32 μg/ml) and amphetamine at a non-toxic level (0.06 μg/ml). Amphetamine was also found in his hair, suggesting prior use. The combination likely caused a severe, adverse interaction.

DOI: 10.2478/s13382-014-0290-8