Rui Daniel Prediger

2 papers in the library · publishing 2026

Papers

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Antidepressant effect of psychedelic compounds and mechanisms underlying the G protein-coupled receptors activation psychedelics: Antidepressant action and GPCR signaling.

European Journal of Pharmacology July 10, 2026 Amanda Gollo Bertollo, Vinicius Alexandre Wippel, Maiqueli Eduarda Dama Mingoti et al.

Major Depressive Disorder (MDD) is a debilitating mental health condition that significantly impacts quality of life. Despite available pharmacological treatments, response rates remain suboptimal, with a considerable number of patients experiencing treatment-resistant depression (TRD). Indeed, classical antidepressants, primarily targeting monoaminergic systems, exhibit a therapeutic delay due...

DOI: 10.1016/j.ejphar.2026.179036 Full text 5-ht2a receptor Antidepressant action G protein-coupled receptors Psychedelic compounds

Acute ketamine withdrawal disrupts memory and monoaminergic neurotransmission in adolescent female rats.

Behavioural Brain Research March 28, 2026 Lucas Villar Pedrosa Da Silva Pantoja, Luiza Fernanda Ramos Soares, Brenda Costa Da Conceição et al.

Adolescence is a period of profound behavioral changes associated with high brain vulnerability to negative stimuli including psychotropic drugs misuse which may contribute to the development of psychiatric disorders. Ketamine, an NMDA receptor antagonist, is an anesthetic agent used in a recreational manner in night clubs and raves, especially by intranasal route. The psychedelic effects of...

DOI: 10.1016/j.bbr.2026.116048 Full text Ketamine Adolescence Cognition Memory +2