Ventral pallidal perineuronal nets regulate opioid relapse.
bioRxiv : the preprint server for biology January 22, 2026 Margareth Nogueira, Giuseppe Giannotti, Carley N Miller et al.
Opioid use disorder remains a major health challenge worldwide. Neuronal activity in the ventral pallidum (VP) regulates opioid reward and relapse to opioid seeking but the underlying cellular mechanisms remain largely unknown. A sizable population of VP neurons previously linked to drug relapse expresses the calcium binding protein parvalbumin (VP PV ). Across the brain parvalbumin neurons are...