Generation of enantiospecific monoclonal antibodies against (2R,6R)-hydroxynorketamine.
Bioorganic & medicinal chemistry January 17, 2026 Uriel Matthew Enriquez, Natalie M González Velázquez, Mohammad Mosharraf Hossain et al.
Antibodies against small psychoactive molecules have been developed for applications ranging from substance detection and overdose protection to mechanistic understanding of the actions of complex substance mixtures. In this study, we describe the design, synthesis, formulation, and animal testing of an initial immunogenic bioconjugate, as well as subsequent isolation of enantiospecific...