Dissociating pain dimensions in cold allodynia: subanesthetic ketamine reveals heritable affective-motivational traits in mice.
Pain January 29, 2026 Nicole Richter, Stefanie Schmidt, Glauce Regina Pigatto et al.
Pain perception involves somatosensory-discriminative and affective-motivational components, mediated by separate brain circuits. Traditional mouse behavioral assays lack the resolution to disentangle this complexity. Recent studies using subanesthetic ketamine doses in the hot-plate test revealed a dissociation between paw lifts (somatosensory) and bites & licks (affective). In this study, we...
DOI: 10.1097/j.pain.0000000000003912 (opens in new tab)
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Affective-motivational pain
Cold allodynia
Inbred mouse strains
Ketamine metabolism
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