Major Depressive Disorder is a common and disabling psychiatric illness whose pharmacological treatment options have historically been characterized by relatively low response rates. "Treatment-resistant depression" has emerged to describe patients whose depressive symptoms fail to respond to multiple courses of oral antidepressant medications. In 2019, the FDA approved intranasal esketamine as...
Major Depressive Disorder is one of the most common mental illnesses worldwide, with oral antidepressant medication being the first-line psychopharmacological treatment option. The term Treatment Resistant Depression (TRD) is used to describe patients who remain symptomatic despite multiple trials of antidepressant medication. There had been limited FDA-approved treatment options for patients...
We present the case of a 75-year-old female presenting with an acute mental status change during which she abruptly became nonresponsive and collapsed to the floor. History revealed years of similar episodes in the context of religious beliefs regarding demonic possession and hearing the voices of God and the Devil. Top experts in the field provide perspective and guidance for diagnosing and...