Age-related moderation of adjunctive psychotherapy and early life stress effects on depression symptom reductions following ketamine treatment: Initial insights from a large, naturalistic sample.
Journal of Affective Disorders February 4, 2026 Raquel Kosted, Alli Waddell, Ken Adolph et al.
Ketamine is known to be a rapid-acting antidepressant, but there is limited evidence regarding which types of patients are best-suited to this treatment and whether adjunctive psychotherapy improves outcomes. In a sample of 224 patients who received five ketamine infusions at a private clinic, this study uses Bayesian mixed modeling to examine the effects of early life stress (measured with the...
DOI: 10.1016/j.jad.2026.121350 (opens in new tab)
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Depression
Major depressive disorder
Adverse childhood experiences
Early life stress
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