Rebecca J Simpson

Effectiveness of ketamine-assisted psychotherapy as a treatment for treatment-resistant depression: a systematic review.

Psychopharmacology February 7, 2026 Rebecca J Simpson, Mario F Juruena 1 citation

Major Depressive Disorder (MDD) is a common and debilitating condition. Current treatments fail to provide adequate relief in roughly one-third of individuals, resulting in treatment-resistant depression (TRD). Ketamine has emerged as a promising intervention for TRD, offering rapid and sustained antidepressant effects. However, benefits often require maintenance dosing, and long-term outcomes...