Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
UNC Libraries June 7, 2024 Kami Kim, Tao Che, Ouliana Panova et al.
Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions—both therapeutic and hallucinogenic—are not understood, although activation of...